Effects of 2164U90 on ileal bile acid absorption and serum cholesterol in rats and mice.
2164U90, [(3R,5R)-trans-3-butyl-3-ethyl-2,3,4,5-tetrahydro-5-phenyl-1,4- benzothiazepine 1,1-dioxide], was found to be a potent inhibitor of the ileal bile acid active transport system. In vitro, 2164U90 decreased uptake and active transport of taurocholic acid by rat everted ileal sacs with IC50s o...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
1995-05-01
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Series: | Journal of Lipid Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520398680 |