Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

The characteristics of immune cells in the peripheral nervous system (PNS) are not fully understood. Here the authors examine the transcriptomic profile and ontogeny of macrophages from the PNS, show they are derived from both embryonic and hematopoietic precursors, and that they have some shared fe...

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Bibliographic Details
Main Authors: Peter L. Wang, Aldrin K. Y. Yim, Ki-Wook Kim, Denis Avey, Rafael S. Czepielewski, Marco Colonna, Jeffrey Milbrandt, Gwendalyn J. Randolph
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16355-w