Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.

Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.

The IGROVCDDP cisplatin-resistant ovarian cancer cell line is also resistant to paclitaxel and models the resistance phenotype of relapsed ovarian cancer patients after first-line platinum/taxane chemotherapy. A TaqMan low-density array (TLDA) was used to characterise the expression of 380 genes ass...

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Bibliographic Details
Main Authors: Britta Stordal, Marion Hamon, Victoria McEneaney, Sandra Roche, Jean-Pierre Gillet, John J O'Leary, Michael Gottesman, Martin Clynes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3394717?pdf=render

Internet

http://europepmc.org/articles/PMC3394717?pdf=render

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