The Impact of Plasma Protein Binding Characteristics and Unbound Concentration of Voriconazole on Its Adverse Drug Reactions

The Impact of Plasma Protein Binding Characteristics and Unbound Concentration of Voriconazole on Its Adverse Drug Reactions

This study investigated voriconazole (VRC) unbound plasma concentration and its relationship with adverse drug reactions (ADRs) in patients with malignant hematologic disease. Plasma samples were collected from patients or spiked in vitro. A time-saving rapid equilibrium dialysis assay was used for...

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Bibliographic Details
Main Authors: Zi-Qing-Yun Yuan, Chun Qiao, Zhi-Cheng Yang, Lei Yu, Lu-Ning Sun, Yi Qian, Xue-Hui Zhang, Ling Meng, Xiao-Yan Zhang, Yong-Qing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
protein binding rate
unbound drug concentration
albumin
α1-acid glycoprotein
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00505/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00505/full

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