TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation.

TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation.

The Epstein-Barr virus (EBV) encoded oncoprotein Latent Membrane Protein 1 (LMP1) signals through two C-terminal tail domains to drive cell growth, survival and transformation. The LMP1 membrane-proximal TES1/CTAR1 domain recruits TRAFs to activate MAP kinase, non-canonical and canonical NF-kB pathw...

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Bibliographic Details
Main Authors: Hannah Greenfeld, Kaoru Takasaki, Michael J Walsh, Ina Ersing, Katharina Bernhardt, Yijie Ma, Bishi Fu, Camille W Ashbaugh, Jackson Cabo, Sarah B Mollo, Hufeng Zhou, Shitao Li, Benjamin E Gewurz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004890

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https://doi.org/10.1371/journal.ppat.1004890

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