Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathway.

Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathway.

INTRODUCTION: Adiponectin (APN), an adipocytokine, exerts protective effects on cardiac remodeling, while angiotensin II (Ang II) induces hypertension and vascular remodeling. The potential protective role of APN on the vasculature during hypertension has not been fully elucidated yet. Here, we eval...

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Bibliographic Details
Main Authors: Wared eNour-Eldine, Crystal M eGhantous, Kazem eZibara, Leila eDib, Hawra eIssa, Hana Ahmad Itani, Nabil eEl-Zein, Asad eZeidan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Pharmacology
Subjects:
Adiponectin
Angiotensin II
Nitric Oxide
remodeling
VSMC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00086/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00086/full

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