Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation.

Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation.

Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer's disease (AD) have largely been developed using these classical laboratory strains, such as C57BL/6J (B6), and this has likely contributed to the failure...

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Main Authors: Kristen D Onos, Asli Uyar, Kelly J Keezer, Harriet M Jackson, Christoph Preuss, Casey J Acklin, Rita O'Rourke, Rebecca Buchanan, Travis L Cossette, Stacey J Sukoff Rizzo, Ileana Soto, Gregory W Carter, Gareth R Howell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008155

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https://doi.org/10.1371/journal.pgen.1008155

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