Melphalan as a Promising Treatment for BRCA-Related Ovarian Carcinoma

Melphalan as a Promising Treatment for BRCA-Related Ovarian Carcinoma

IntroductionMelphalan, as a bifunctional alkylating agent has been shown to be selectively efficient in BRCA-deficient case reports of epithelial ovarian cancer (EOC). The clinical benefit of melphalan on unselected platinum-resistant EOC population and stratified by BRCA status has not been clearly...

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Bibliographic Details
Main Authors: Vincenza Conteduca, Emanuela Scarpi, Alberto Farolfi, Nicole Brighi, Lorena Rossi, Giorgia Gurioli, Cristian Lolli, Giuseppe Schepisi, Sara Bleve, Caterina Gianni, Alessandra Virga, Amelia Altavilla, Salvatore Luca Burgio, Cecilia Menna, Ugo De Giorgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
melphalan
ovarian cancer
BRCA
platinum resistance
survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.716467/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.716467/full

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