In vitro-Induced Human IL-10+ B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines

In vitro-Induced Human IL-10+ B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines

Regulatory B cells (Breg) have been described as a specific immunological subsets in several mouse models. Identification of a human counterpart has remained troublesome, because unique plasma membrane markers or a defining transcription factor have not been identified. Consequently, human Bregs are...

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Bibliographic Details
Main Authors: Laura C. Lighaam, Peter-Paul A. Unger, David W. Vredevoogd, Dorit Verhoeven, Ellen Vermeulen, Annelies W. Turksma, Anja ten Brinke, Theo Rispens, S. Marieke van Ham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
immune regulation
Breg
IL-10
IL-6
t-SNE analysis
B cell plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01913/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01913/full

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