Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.

Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions. Its mode of action was proposed to involve inhibition of increased GRP78 (glucose regulated protein 78)...

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Bibliographic Details
Main Authors: Simmy Thomas, Natasha Sharma, Reyna Gonzalez, Peng-Wen Pao, Florence M Hofman, Thomas C Chen, Stan G Louie, Michael C Pirrung, Axel H Schönthal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675020?pdf=render

Internet

http://europepmc.org/articles/PMC3675020?pdf=render

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