Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Abstract The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune respo...

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Bibliographic Details
Main Authors: Mi Li, Hong-Bing Shu
Format: Article
Language:English
Published: SpringerOpen 2020-05-01
Series:Protein & Cell
Subjects:
DNA virus
PPP6C
cGAS
innate immune response
phosphorylation
substrate binding
Online Access:https://doi.org/10.1007/s13238-020-00729-3

Internet

https://doi.org/10.1007/s13238-020-00729-3

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