Acquired and Innate Immunity Impairment and Severe Disseminated Mycobacterium genavense Infection in a Patient With a NF-κB1 Deficiency

Acquired and Innate Immunity Impairment and Severe Disseminated Mycobacterium genavense Infection in a Patient With a NF-κB1 Deficiency

Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-function mutations elicit a wide clinical phenotype with asymptomatic individuals at one end of the spectrum and patients with common variable immunodeficiency, combined immunodeficiency or autoinflammation...

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Bibliographic Details
Main Authors: Luis Ignacio Gonzalez-Granado, Raquel Ruiz-García, Javier Blas-Espada, José Manuel Moreno-Villares, Marta Germán-Diaz, Marta López-Nevado, Estela Paz-Artal, Oscar Toldos, Yolanda Rodriguez-Gil, Jaime de Inocencio, Nerea Domínguez-Pinilla, Luis M. Allende
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB1 gene
primary immunodeficiency
common variable immunodeficiency
mendelian susceptibility to mycobacterial disease
Mycobacterium genavense
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03148/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03148/full

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