Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles

Axially chiral arylpyrroles are structural motifs often found in natural and medicinal products. Here, the authors report the atroposelective synthesis of axially chiral arylpyrrole derivatives, which proved to be efficient chiral ligands for asymmetric catalysis, through desymmetrization and kineti...

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Bibliographic Details
Main Authors: Lei Zhang, Shao-Hua Xiang, Jun (Joelle) Wang, Jian Xiao, Jun-Qi Wang, Bin Tan
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08447-z