Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles

Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles

The Eph (erythropoietin-producing hepatocellular carcinoma) B receptors are important in a variety of cellular processes through their roles in cell-to-cell contact and signalling; their up-regulation and down-regulation has been shown to have implications in a variety of cancers. A greater understa...

Full description

Bibliographic Details
Main Authors: Ross C. Overman, Judit E. Debreczeni, Caroline M. Truman, Mark S. McAlister, Teresa K. Attwood
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-06-01
Series:Bioscience Reports
Subjects:
EphB1
EphB2
EphB3
EphB4
kinase inhibition
protein stability
Online Access:http://www.bioscirep.org/bsr/033/e040/bsr033e040.htm

Internet

http://www.bioscirep.org/bsr/033/e040/bsr033e040.htm

Similar Items