NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

Summary: Frameshifted protein sequences elicit tumor-specific T cell-mediated immune responses in microsatellite-unstable (MSI) cancers if presented by HLA class I molecules. However, their expression and presentation are limited by nonsense-mediated RNA decay (NMD). We employed an unbiased immunope...

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Bibliographic Details
Main Authors: Jonas P. Becker, Dominic Helm, Mandy Rettel, Frank Stein, Alejandro Hernandez-Sanchez, Katharina Urban, Johannes Gebert, Matthias Kloor, Gabriele Neu-Yilik, Magnus von Knebel Doeberitz, Matthias W. Hentze, Andreas E. Kulozik
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Biological Sciences
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003576

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221003576

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