CD4+ T Cell Defects in a Mulibrey Patient With Specific TRIM37 Mutations

CD4+ T Cell Defects in a Mulibrey Patient With Specific TRIM37 Mutations

Mulibrey (muscle-liver-brain-eye) syndrome (MUL) is an autosomal recessive disorder caused by mutations in the TRIpartite motif (TRIM)37 gene, encoding for TRIM37 a member of the TRIM E3 ubiquitin ligase protein family. MUL patients are characterized by growth retardation, dysmorphic features, and a...

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Bibliographic Details
Main Authors: Sara Bruzzaniti, Emilia Cirillo, Rosaria Prencipe, Giuliana Giardino, Maria Teresa Lepore, Federica Garziano, Francesco Perna, Claudio Procaccini, Luigi Mascolo, Cristina Pagano, Valentina Fattorusso, Enza Mozzillo, Maurizio Bifulco, Giuseppe Matarese, Adriana Franzese, Claudio Pignata, Mario Galgani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
immune response
CD4+ T cells
immunological defects
TRIM37
Mulibrey syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01742/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01742/full

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