Pre-transplant MRD negativity predicts favorable outcomes of CAR-T therapy followed by haploidentical HSCT for relapsed/refractory acute lymphoblastic leukemia: a multi-center retrospective study

Pre-transplant MRD negativity predicts favorable outcomes of CAR-T therapy followed by haploidentical HSCT for relapsed/refractory acute lymphoblastic leukemia: a multi-center retrospective study

Abstract Background Consolidative allogeneic hematopoietic stem cell transplantation is a controversial option for patients with relapsed/refractory acute lymphoblastic leukemia after chimeric antigen receptor T cell (CAR-T) therapy. We performed a multicenter retrospective study to assess whether p...

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Bibliographic Details
Main Authors: Houli Zhao, Jieping Wei, Guoqing Wei, Yi Luo, Jimin Shi, Qu Cui, Mingfeng Zhao, Aibin Liang, Qing Zhang, Jianmin Yang, Xin Li, Jing Chen, Xianmin Song, Hongmei Jing, Yuhua Li, Siguo Hao, Wenjun Wu, Yamin Tan, Jian Yu, Yanmin Zhao, Xiaoyu Lai, Elaine Tan Su Yin, Yunxiong Wei, Ping Li, Jing Huang, Tao Wang, Didier Blaise, Lei Xiao, Alex H. Chang, Arnon Nagler, Mohamad Mohty, He Huang, Yongxian Hu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Hematology & Oncology
Subjects:
Chimeric antigen receptor T cell therapy
Haploidentical hematopoietic stem cell transplantation
Leukemia-free survival
Minimal residual disease negativity
Overall survival
Relapsed/refractory acute lymphoblastic leukemia
Online Access:http://link.springer.com/article/10.1186/s13045-020-00873-7

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http://link.springer.com/article/10.1186/s13045-020-00873-7

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