Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests

Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests

Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are associated with painful conditions and accelerated intervertebral disc (IVD) degeneration. Currently, no effective treatments exist to repair AF damage, restore IVD biomechanics and promote tissue regeneratio...

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Bibliographic Details
Main Authors: M Likhitpanichkul, M Dreischarf, S Illien-Junger, BA Walter, T Nukaga, RG Long, D Sakai, AC Hecht, JC Iatridis
Format: Article
Language:English
Published: AO Research Institute Davos 2014-07-01
Series:European Cells & Materials
Subjects:
Intervertebral disc
annulus fibrosus repair
injectable hydrogel
fibrin-genipin
adhesive biomaterial
organ culture
motion segment testing
in vivo degradation
herniation
discectomy
Online Access:http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a03.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a03.pdf

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