Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations

Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations

Mutation-derived neoantigens are important targets for T cell-mediated reactivity toward tumors and, due to their unique tumor expression, an attractive target for immunotherapy. Neoepitope-specific T cells have been detected across a number of solid cancers with high mutational burden tumors, but n...

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Bibliographic Details
Main Authors: Ulla Kring Hansen, Sofie Ramskov, Anne-Mette Bjerregaard, Annie Borch, Rikke Andersen, Arianna Draghi, Marco Donia, Amalie Kai Bentzen, Andrea Marion Marquard, Zoltan Szallasi, Aron Charles Eklund, Inge Marie Svane, Sine Reker Hadrup
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
renal cell carcinoma
neoepitopes
neoantigens
frameshift mutations
T cell screening
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00373/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00373/full

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