Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique properties of this amino acid, such as abi...

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Bibliographic Details
Main Authors: Areetha R. D’Souza, Matthew R. Necelis, Alona Kulesha, Gregory A. Caputo, Olga V. Makhlynets
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
antimicrobial peptides
fluorescence
lipid binding
buCATHL4B
non-natural amino acids
protease resistance
Online Access:https://www.mdpi.com/2218-273X/11/3/421

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https://www.mdpi.com/2218-273X/11/3/421

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