Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration

Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration

Summary: CNS cortical histogenesis depends on polarity signaling pathways that regulate cell adhesion and motility. Here we report that conditional deletion of the Rho GTPase Cdc42 in cerebellar granule cell precursors (GCPs) results in abnormalities in cerebellar foliation revealed by iDISCO cleari...

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Bibliographic Details
Main Authors: Eve-Ellen Govek, Zhuhao Wu, Devrim Acehan, Henrik Molina, Keith Rivera, Xiaodong Zhu, Yin Fang, Marc Tessier-Lavigne, Mary Elizabeth Hatten
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421830004X

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http://www.sciencedirect.com/science/article/pii/S258900421830004X

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