Metabolites of alectinib in human: their identification and pharmacological activity

Metabolites of alectinib in human: their identification and pharmacological activity

Two metabolites (M4 and M1b) in plasma and four metabolites (M4, M6, M1a and M1b) in faeces were detected through the human ADME study following a single oral administration of [14C]alectinib, a small-molecule anaplastic lymphoma kinase inhibitor, to healthy subjects. In the present study, M1a and M...

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Bibliographic Details
Main Authors: Mika Sato-Nakai, Kosuke Kawashima, Toshito Nakagawa, Yukako Tachibana, Miyuki Yoshida, Kenji Takanashi, Peter N. Morcos, Martin Binder, David J Moore, Li Yu
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Heliyon
Subjects:
Metabolism
Cancer research
Pharmaceutical science
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844017311684

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http://www.sciencedirect.com/science/article/pii/S2405844017311684

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