Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear neutrophil granulocytes (PMN) express high levels...

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Bibliographic Details
Main Authors: Verena Vonwirth, Yagmur Bülbül, Anke Werner, Hakim Echchannaoui, Johannes Windschmitt, Alice Habermeier, Sonia Ioannidis, Niu Shin, Roland Conradi, Matthias Bros, Stefan Tenzer, Matthias Theobald, Ellen Ildicho Closs, Markus Munder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
T cell
activation
human
granulocyte
arginase 1
neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.617699/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.617699/full

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