Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice

Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice

In the YAC128 mouse model of Huntington disease (HD), elevated extrasynaptic NMDA receptor (Ex-NMDAR) expression contributes to the onset of striatal dysfunction and atrophy. A shift in the balance of synaptic–extrasynaptic NMDAR signaling and localization is paralleled by early stage dysregulation...

Full description

Bibliographic Details
Main Authors: Alejandro Dau, Clare M. Gladding, Marja D. Sepers, Lynn A. Raymond
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
NMDA receptor
GluN2B
Extrasynaptic
p38
pCREB
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003252

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113003252

Similar Items