Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.

Therapeutic targeting of host cell factors required for virus replication rather than of pathogen components opens new perspectives to counteract virus infections. Anticipated advantages of this approach include a heightened barrier against the development of viral resistance and a broadened pathoge...

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Bibliographic Details
Main Authors: Stefanie A Krumm, J Maina Ndungu, Jeong-Joong Yoon, Melanie Dochow, Aiming Sun, Michael Natchus, James P Snyder, Richard K Plemper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3095640?pdf=render

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http://europepmc.org/articles/PMC3095640?pdf=render

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