Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

<p>Abstract</p> <p>Background</p> <p>Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression. Microglial activation can be induced by Aβ, but the mec...

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Bibliographic Details
Main Authors: Kauppinen Tiina M, Suh Sang, Higashi Youichirou, Berman Ari E, Escartin Carole, Won Seok, Wang Chao, Cho Seo-Hyun, Gan Li, Swanson Raymond A
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer's disease
beta amyloid peptide
calbindin
cytokines
microglia
NF-κB
poly(ADP-ribose)polymerase-1
trophic factors
Online Access:http://www.jneuroinflammation.com/content/8/1/152

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http://www.jneuroinflammation.com/content/8/1/152

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