Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

Surfactant accumulates in alveolar macrophages of granulocyte-macrophage colony-stimulating factor (GM-CSF) knockout (KO) mice and pulmonary alveolar proteinosis (PAP) patients with a functional loss of GM-CSF resulting from neutralizing anti–GM-CSF antibody. Alveolar macrophages from PAP patients a...

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Bibliographic Details
Main Authors: Anna D. Baker, Anagha Malur, Barbara P. Barna, Shobha Ghosh, Mani S. Kavuru, Achut G. Malur, Mary Jane Thomassen
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of Lipid Research
Subjects:
pulmonary alveolar proteinosis
granulocyte-macrophage colony-stimulating factor
peroxisome proliferator-activated receptor-γ
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410065

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http://www.sciencedirect.com/science/article/pii/S0022227520410065

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