In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

Synucleinopathies are a group of diseases characterized by the presence of intracellular protein aggregates containing α-synuclein (α-syn). While α-syn aggregates have been shown to induce multimodal cellular dysfunctions, uptake and transport mechanisms remain unclear. Using high-content imaging on...

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Bibliographic Details
Main Authors: Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
High-throughput
96-well plate
Microfluidic
High content imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300852

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http://www.sciencedirect.com/science/article/pii/S0969996117300852

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