Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents

Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents

New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to examine the correlation between anticancer activity and cholinesterases, the comp...

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Bibliographic Details
Main Authors: Mehlika Dilek Altıntop, Halide Edip Temel, Belgin Sever, Gülşen Akalın Çiftçi, Zafer Asım Kaplancıklı
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
thiosemicarbazone
benzodioxole
cancer
apoptosis
mitochondrial membrane potential
SIRT1
docking studies
Online Access:http://www.mdpi.com/1420-3049/21/11/1598

Internet

http://www.mdpi.com/1420-3049/21/11/1598

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