Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity
Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adip...
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doaj-0dbf741b8cf24349b75aa4232a0c19272020-11-24T21:15:54ZengElsevierCell Reports2211-12472018-01-012241079108910.1016/j.celrep.2017.12.102Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with ObesityValentin Barquissau0Benjamin Léger1Diane Beuzelin2Frédéric Martins3Ez-Zoubir Amri4Didier F. Pisani5Wim H.M. Saris6Arne Astrup7Jean-José Maoret8Jason Iacovoni9Sébastien Déjean10Cédric Moro11Nathalie Viguerie12Dominique Langin13INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceUniversity of Côte d’Azur, CNRS, Inserm, iBV, Nice, FranceUniversity of Côte d’Azur, CNRS, Inserm, iBV, Nice, FranceDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the NetherlandsDepartment of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Copenhagen, DenmarkINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceUniversity of Toulouse, Paul Sabatier University, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceINSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, FranceCaloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent of changes in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneous abdominal WAT browning in people with obesity.http://www.sciencedirect.com/science/article/pii/S221112471731954Xhuman obesitycaloric restrictiondietary interventionsubcutaneous abdominal white adipose tissuebrowning of white fatuncoupling protein 1sex differenceinsulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentin Barquissau Benjamin Léger Diane Beuzelin Frédéric Martins Ez-Zoubir Amri Didier F. Pisani Wim H.M. Saris Arne Astrup Jean-José Maoret Jason Iacovoni Sébastien Déjean Cédric Moro Nathalie Viguerie Dominique Langin |
spellingShingle |
Valentin Barquissau Benjamin Léger Diane Beuzelin Frédéric Martins Ez-Zoubir Amri Didier F. Pisani Wim H.M. Saris Arne Astrup Jean-José Maoret Jason Iacovoni Sébastien Déjean Cédric Moro Nathalie Viguerie Dominique Langin Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity Cell Reports human obesity caloric restriction dietary intervention subcutaneous abdominal white adipose tissue browning of white fat uncoupling protein 1 sex difference insulin resistance |
author_facet |
Valentin Barquissau Benjamin Léger Diane Beuzelin Frédéric Martins Ez-Zoubir Amri Didier F. Pisani Wim H.M. Saris Arne Astrup Jean-José Maoret Jason Iacovoni Sébastien Déjean Cédric Moro Nathalie Viguerie Dominique Langin |
author_sort |
Valentin Barquissau |
title |
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity |
title_short |
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity |
title_full |
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity |
title_fullStr |
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity |
title_full_unstemmed |
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity |
title_sort |
caloric restriction and diet-induced weight loss do not induce browning of human subcutaneous white adipose tissue in women and men with obesity |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2018-01-01 |
description |
Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent of changes in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneous abdominal WAT browning in people with obesity. |
topic |
human obesity caloric restriction dietary intervention subcutaneous abdominal white adipose tissue browning of white fat uncoupling protein 1 sex difference insulin resistance |
url |
http://www.sciencedirect.com/science/article/pii/S221112471731954X |
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