Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.

Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells.

Elevated levels of systemic IL-10 have been associated with several chronic viral infections, including HCV, EBV, HCMV and LCMV. In the chronic LCMV infection model, both elevated IL-10 and enhanced infection of dendritic cells (DCs) are important for viral persistence. This report highlights the re...

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Bibliographic Details
Main Authors: Carmen Baca Jones, Christophe Filippi, Sowbarnika Sachithanantham, Teresa Rodriguez-Calvo, Katrin Ehrhardt, Matthias von Herrath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3948950?pdf=render

Internet

http://europepmc.org/articles/PMC3948950?pdf=render

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