Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production

Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production

Abstract Background The pathogenesis of lupus nephritis (LN) remains not fully understood. In this study, we aimed to explore the pathogenic roles of autoantibodies against human renal glomerular endothelial cells (HRGEC) in LN patients. Methods The serum levels of anti-HRGEC antibodies in systemic...

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Bibliographic Details
Main Authors: Ya-Chiao Hu, I-Jung Tsai, Hui-Yao Hsu, Bor-Luen Chiang, Yao-Hsu Yang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Arthritis Research & Therapy
Subjects:
Lupus nephritis
Monoclonal antibody
Human renal glomerular endothelial cells
Interferon-α
Online Access:https://doi.org/10.1186/s13075-021-02552-5

Internet

https://doi.org/10.1186/s13075-021-02552-5

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