Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Abstract Background Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative functions, may facilitate research towards curing neurodegenerative disorders. In the present study, we investigated whether tar...

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Bibliographic Details
Main Authors: Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
Microglia/macrophage polarization
Interleukin 13
Mesenchymal stem cells
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1212-7

Internet

http://link.springer.com/article/10.1186/s12974-018-1212-7

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