BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

Deubiquitinase BAP1 is an important tumor suppressor in several malignancies, but its functions and critical substrates in prostate cancer (PCa) remain unclear. Here, we report that the mRNA and protein expression levels of BAP1 are downregulated in clinical PCa specimens. BAP1 can physically bind t...

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Bibliographic Details
Main Authors: Rong Deng, Yanmin Guo, Lian Li, Jianfeng He, Zhe Qiang, Hailong Zhang, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Molecular Oncology
Subjects:
BAP1
cancer progression
deubiquitination
prostate cancer
PTEN
Online Access:https://doi.org/10.1002/1878-0261.12844

Internet

https://doi.org/10.1002/1878-0261.12844

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