Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research
In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear pro...
Main Authors: | Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan G. Williams, Adrienne Mottis, Virginija Jovaisaite, Michael V. Frochaux, Pedro M. Quiros, Bart Deplancke, Riekelt H. Houtkooper, Johan Auwerx |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-03-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715001801 |
Similar Items
-
The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
by: Mouchiroud, Laurent, et al.
Published: (2015) -
An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.
by: Evan G Williams, et al.
Published: (2014-09-01) -
Tetracycline Loaded Collagen/Hydroxyapatite Composite Materials for Biomedical Applications
by: Laura Cristina Rusu, et al.
Published: (2015-01-01) -
Identification and validation of a potent synthetic TGR5 agonist that improves metabolism, inflammation and atherosclerosis
by: Moullan, Norman
Published: (2015) -
Caution and necessity
by: José Edgar González Varela
Published: (2013-12-01)