Heterozygous variant in WNT1 gene in two brothers with early onset osteoporosis

Heterozygous variant in WNT1 gene in two brothers with early onset osteoporosis

Osteoporosis is a multifactorial disorder characterized by low bone mass and strength, leading to increased risk of fracture. The WNT pathway plays a critical role in bone remodeling by enhancing osteoblastic differentiation, which promotes bone formation, and inhibiting osteoclastic differentiation...

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Bibliographic Details
Main Authors: Christie G. Turin, Kyu Sang Joeng, Staci Kallish, Anna Raper, Stephanie Asher, Philippe M. Campeau, Amna N. Khan, Mona Al Mukaddam
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Bone Reports
Subjects:
WNT1 pathway
Genetic variant
Early osteoporosis
Fragility fractures
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187221003752

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http://www.sciencedirect.com/science/article/pii/S2352187221003752

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