The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases
Epigenetic mechanisms, including DNA and histone modifications, are pivotal for normal brain development and functions by modulating spatial and temporal gene expression. Dysregulation of the epigenetic machinery can serve as a causal role in numerous brain disorders. Proper mammalian brain developm...
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2019-08-01
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Online Access: | https://www.mdpi.com/2075-4655/3/3/17 |
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doaj-0dd14be525e54d8289ec502c8c7d78462021-04-02T05:17:28ZengMDPI AGEpigenomes2075-46552019-08-01331710.3390/epigenomes3030017epigenomes3030017The Dynamic Partnership of Polycomb and Trithorax in Brain Development and DiseasesJanise N. Kuehner0Bing Yao1Department of Human Genetics, Emory University School of Medicine, Atlanta 30322, GA, USADepartment of Human Genetics, Emory University School of Medicine, Atlanta 30322, GA, USAEpigenetic mechanisms, including DNA and histone modifications, are pivotal for normal brain development and functions by modulating spatial and temporal gene expression. Dysregulation of the epigenetic machinery can serve as a causal role in numerous brain disorders. Proper mammalian brain development and functions depend on the precise expression of neuronal-specific genes, transcription factors and epigenetic modifications. Antagonistic polycomb and trithorax proteins form multimeric complexes and play important roles in these processes by epigenetically controlling gene repression or activation through various molecular mechanisms. Aberrant expression or disruption of either protein group can contribute to neurodegenerative diseases. This review focus on the current progress of Polycomb and Trithorax complexes in brain development and disease, and provides a future outlook of the field.https://www.mdpi.com/2075-4655/3/3/17epigeneticspolycombtrithoraxbrain developmentneurodegenerationAlzheimer’s DiseaseHuntington’s DiseaseParkinson’s Disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Janise N. Kuehner Bing Yao |
spellingShingle |
Janise N. Kuehner Bing Yao The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases Epigenomes epigenetics polycomb trithorax brain development neurodegeneration Alzheimer’s Disease Huntington’s Disease Parkinson’s Disease |
author_facet |
Janise N. Kuehner Bing Yao |
author_sort |
Janise N. Kuehner |
title |
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases |
title_short |
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases |
title_full |
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases |
title_fullStr |
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases |
title_full_unstemmed |
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases |
title_sort |
dynamic partnership of polycomb and trithorax in brain development and diseases |
publisher |
MDPI AG |
series |
Epigenomes |
issn |
2075-4655 |
publishDate |
2019-08-01 |
description |
Epigenetic mechanisms, including DNA and histone modifications, are pivotal for normal brain development and functions by modulating spatial and temporal gene expression. Dysregulation of the epigenetic machinery can serve as a causal role in numerous brain disorders. Proper mammalian brain development and functions depend on the precise expression of neuronal-specific genes, transcription factors and epigenetic modifications. Antagonistic polycomb and trithorax proteins form multimeric complexes and play important roles in these processes by epigenetically controlling gene repression or activation through various molecular mechanisms. Aberrant expression or disruption of either protein group can contribute to neurodegenerative diseases. This review focus on the current progress of Polycomb and Trithorax complexes in brain development and disease, and provides a future outlook of the field. |
topic |
epigenetics polycomb trithorax brain development neurodegeneration Alzheimer’s Disease Huntington’s Disease Parkinson’s Disease |
url |
https://www.mdpi.com/2075-4655/3/3/17 |
work_keys_str_mv |
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