New open conformation of SMYD3 implicates conformational selection and allostery

New open conformation of SMYD3 implicates conformational selection and allostery

SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured fu...

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Bibliographic Details
Main Authors: Nicholas Spellmon, Xiaonan Sun, Wen Xue, Joshua Holcomb, Srinivas Chakravarthy, Weifeng Shang, Brian Edwards, Nualpun Sirinupong, Chunying Li, Zhe Yang
Format: Article
Language:English
Published: AIMS Press 2016-12-01
Series:AIMS Biophysics
Subjects:
lysine methyltransferase
MYND- and SET-domain containing protein
epigenetics
Online Access:http://www.aimspress.com/biophysics/article/1166/fulltext.html

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http://www.aimspress.com/biophysics/article/1166/fulltext.html

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