New open conformation of SMYD3 implicates conformational selection and allostery
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured fu...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
AIMS Press
2016-12-01
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Series: | AIMS Biophysics |
Subjects: | |
Online Access: | http://www.aimspress.com/biophysics/article/1166/fulltext.html |