Non-invasive Chemokine Detection: Improved Prediction of Antibody-Mediated Rejection in Donor-Specific Antibody-Positive Renal Allograft Recipients

Non-invasive Chemokine Detection: Improved Prediction of Antibody-Mediated Rejection in Donor-Specific Antibody-Positive Renal Allograft Recipients

Background: Screening for donor-specific antibodies (DSA) has limited diagnostic value in patients with late antibody-mediated rejection (ABMR). Here, we evaluated whether biomarkers reflecting microcirculation inflammation or tissue injury—as an adjunct to DSA detection—are able to improve non-inva...

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Bibliographic Details
Main Authors: Jakob Mühlbacher, Konstantin Doberer, Nicolas Kozakowski, Heinz Regele, Sümeyra Camovic, Susanne Haindl, Gregor Bond, Helmuth Haslacher, Farsad Eskandary, Jeff Reeve, Georg A. Böhmig, Markus Wahrmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Medicine
Subjects:
antibody-mediated rejection (ABMR)
chemokines
chronic rejection
donor-specific antibodies (DSA)
human leukocyte antigene (HLA)
kidney
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00114/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00114/full

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