Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, which develops in the context of fibrosis and cirrhosis caused by chronic inflammation, in turn due to non-alcoholic fatty liver disease (NAFLD), alcohol consumption and/or hepatitis viral infection. An increased number of se...

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Bibliographic Details
Main Authors: Kristina Kovacovicova, Marianna Skolnaja, Mihkel Heinmaa, Martin Mistrik, Pille Pata, Illar Pata, Jiri Bartek, Manlio Vinciguerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
NAFLD (non-alcoholic fatty liver disease)
HCC (hepatocellular carcinoma)
senolytic agents
quercertin
dasatinib
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00459/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00459/full

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