Diverse modes of binding in structures of Leishmania majorN-myristoyltransferase with selective inhibitors

Diverse modes of binding in structures of Leishmania majorN-myristoyltransferase with selective inhibitors

The leishmaniases are a spectrum of global diseases of poverty associated with immune dysfunction and are the cause of high morbidity. Despite the long history of these diseases, no effective vaccine is available and the currently used drugs are variously compromised by moderate efficacy, complex si...

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Bibliographic Details
Main Authors: James A. Brannigan, Shirley M. Roberts, Andrew S. Bell, Jennie A. Hutton, Michael R. Hodgkinson, Edward W. Tate, Robin J. Leatherbarrow, Deborah F. Smith, Anthony J. Wilkinson
Format: Article
Language:English
Published: International Union of Crystallography 2014-07-01
Series:IUCrJ
Subjects:
N-myristoyltransferase
inhibitor
ligand binding
Leishmania
drug discovery
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252514013001

Internet

http://scripts.iucr.org/cgi-bin/paper?S2052252514013001

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