NQO1 Binds and Supports SIRT1 Function

NQO1 Binds and Supports SIRT1 Function

Silent information regulator 2-related enzyme 1 (SIRT1) is an NAD+-dependent class III deacetylase and a key component of the cellular metabolic sensing pathway. The requirement of NAD+ for SIRT1 activity led us to assume that NQO1, an NADH oxidoreductase producing NAD+, regulates SIRT1 activity. We...

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Bibliographic Details
Main Authors: Peter Tsvetkov, Julia Adler, Romano Strobelt, Yaarit Adamovich, Gad Asher, Nina Reuven, Yosef Shaul
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
quinone oxidoreductase 1
NADH/NAD ratio
SIRT1 activity
PGC1 alpha
mitochondria stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.671929/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.671929/full

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