Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis

Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis

BackgroundLncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs in temozolomide (TMZ) resistance in glioblastoma (GBM) remain to be elucidated.MethodsTo elucidate the mechanism maintaining TMZ resistance, we constructed two TMZ-res...

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Bibliographic Details
Main Authors: Yuanliang Yan, Zhijie Xu, Xi Chen, Xiang Wang, Shuangshuang Zeng, Zijin Zhao, Long Qian, Zhi Li, Jie Wei, Lei Huo, Xuejun Li, Zhicheng Gong, Lunquan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glioblastoma
TMZ resistance
ADAMTS9-AS2
FUS
MDM2
ubiquitination
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00217/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00217/full

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