Small-Nucleic-Acid-Based Therapeutic Strategy Targeting the Transcription Factors Regulating the Vascular Inflammation, Remodeling and Fibrosis in Atherosclerosis

Small-Nucleic-Acid-Based Therapeutic Strategy Targeting the Transcription Factors Regulating the Vascular Inflammation, Remodeling and Fibrosis in Atherosclerosis

Atherosclerosis arises when injury to the arterial wall induces an inflammatory cascade that is sustained by a complex network of cytokines, together with accumulation of lipids and fibrous material. Inflammatory cascades involve leukocyte adherence and chemotaxis, which are coordinated by the loc...

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Bibliographic Details
Main Authors: Sung Won Youn, Kwan-Kyu Park
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
atherosclerosis
inflammation
remodeling
fibrosis
transcription factor
gene therapy
oligodeoxynucleotides
Online Access:http://www.mdpi.com/1422-0067/16/5/11804

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http://www.mdpi.com/1422-0067/16/5/11804

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