Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

SUMMARY Mutations in the WAS gene cause Wiskott-Aldrich syndrome (WAS), which is characterized by eczema, immunodeficiency and microthrombocytopenia. Although the role of WASP in lymphocytes and myeloid cells is well characterized, its role on megakaryocyte (MK) development is poorly understood. In...

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Bibliographic Details
Main Authors: Miguel G. Toscano, Per Anderson, Pilar Muñoz, Gema Lucena, Marién Cobo, Karim Benabdellah, Philip D. Gregory, Michael C. Holmes, Francisco Martin
Format: Article
Language:English
Published: The Company of Biologists 2013-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/2/544

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http://dmm.biologists.org/content/6/2/544

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