Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential polyamines have many functions, but are primarily...

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Bibliographic Details
Main Authors: Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Medical Sciences
Subjects:
polyamines
ornithine decarboxylase
difluoromethylornithine
eflornithine
DFMO
African sleeping sickness
hirsutism
colorectal cancer
neuroblastoma
Online Access:http://www.mdpi.com/2076-3271/6/1/12

Internet

http://www.mdpi.com/2076-3271/6/1/12

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