Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation

Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation

Abstract Background High-grade serous ovarian cancer (HGSOC) is the most lethal of all gynecological malignancies. Patients often suffer from chemoresistance. Several studies have reported that Fn14 could regulate migration, invasion, and angiogenesis in cancer cells. However, its functional role in...

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Bibliographic Details
Main Authors: An-Yue Wu, Li-Ying Gu, Wei Cang, Meng-Xing Cheng, Wen-Jing Wang, Wen Di, Lei Huang, Li-Hua Qiu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HGSOC
Cisplatin resistance
Fn14
p53-R248Q
Hsp90
Online Access:http://link.springer.com/article/10.1186/s13046-019-1171-6

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http://link.springer.com/article/10.1186/s13046-019-1171-6

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