Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling

Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal. We conducted this study to investigate the effect of SQLE expressi...

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Bibliographic Details
Main Authors: Hong Ge, Yamei Zhao, Xinyan Shi, Zhen Tan, Xiaorui Chi, Man He, Guohui Jiang, Lixia Ji, Hongmei Li
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Thoracic Cancer
Subjects:
ERK signal
invasion
migration
proliferation
SQLE
Online Access:https://doi.org/10.1111/1759-7714.12944

Internet

https://doi.org/10.1111/1759-7714.12944

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