Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors

Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors

Abstract Background The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking...

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Bibliographic Details
Main Authors: Francesca Paolini, Carla Amici, Mariantonia Carosi, Claudia Bonomo, Paola Di Bonito, Aldo Venuti, Luisa Accardi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HPV-associated cancer
Antitumor intracellular antibodies
Therapeutic single-chain antibody fragments
HPV16 E6 and E7 oncoproteins
Apoptosis
Gene delivery by electroporation
Online Access:https://doi.org/10.1186/s13046-021-01841-w

Internet

https://doi.org/10.1186/s13046-021-01841-w

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