Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

The human pathogen Staphylococcus aureus causes a wide range of infections, including skin abscesses and sepsis. There is currently no licensed vaccine to prevent S. aureus infection, and its treatment has become increasingly difficult due to antibiotic resistance. One potential way to inhibit S. au...

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Bibliographic Details
Main Authors: Monique R. Bennett, Jinhui Dong, Robin G. Bombardi, Cinque Soto, Helen M. Parrington, Rachel S. Nargi, Clara T. Schoeder, Marcus B. Nagel, Kevin L. Schey, Jens Meiler, Eric P. Skaar, James E. Crowe
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
staphylococcus aureus
x-ray crystallography
adaptive immunity
antibody functions
antibody repertoire
computer modeling
humoral immunity
monoclonal antibodies
proteomics
Online Access:https://doi.org/10.1128/mBio.02473-19

Internet

https://doi.org/10.1128/mBio.02473-19

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